abstract：:Recently advances in cancer genomics revealed the unexpected high frequencies of epigenetic abnormalities in human acute myeloid leukemia (AML). Accumulating data suggest that these leukemia-associated epigenetic factors play critical roles in both normal hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs)....

journal_title：Advances in experimental medicine and biology

authors： Xu J,Hang X,Wu B,Chen C,Liu Y

更新日期：2019-01-01 00:00:00

abstract：:As extracts from Ganoderma lucidum (G. lucidum, Lingzhi) have been reported to be an alternative adjuvant treatment for diabetes, numerous of work have been carried out on it. Among the many biologically active constituents of Ganoderma, polysaccharides, proteoglycans, proteins, and triterpenoids have been shown to ha...

journal_title：Advances in experimental medicine and biology

authors： Liu Q,Tie L

更新日期：2019-01-01 00:00:00

abstract：:This study explores brain-computer interfacing, its possible use in serious or educational games and frameworks. Providing real-time feedback regarding cognitive states and behaviours can be a powerful tool for mental health education and games can offer unique and engaging environments for these neurofeedback experie...

journal_title：Advances in experimental medicine and biology

authors： Murdoch R

更新日期：2019-01-01 00:00:00

abstract：:Autophagy, the intracellular degradation and dynamic recycling system, plays critical roles in pluripotent and differentiated cells. It protects the homeostasis of the intracellular environment and maintains the functions of cells by degrading and recycling cytoplasmic components. Autophagy is associated with the enti...

journal_title：Advances in experimental medicine and biology

authors： Liu K,Wang L,Zhao T

更新日期：2019-01-01 00:00:00

abstract：:Autophagy is a catabolic process in eukaryotic cells that delivers cytoplasmic components and organelles to the lysosomes for digestion. It is thought that various environmental signaling pathways are somehow integrated with autophagy signaling, such as the lack of nutrients (amino acids or glucose or others), changes...

journal_title：Advances in experimental medicine and biology

authors： Zhang N,Zhao Y

更新日期：2019-01-01 00:00:00

abstract：:Autophagy plays a crucial role in maintaining cellular homeostasis, and is closely related to the occurrence of variety of human diseases. It is known that autophagy occurs in response to various environmental stresses such as nutrient deficiency, growth factor deficiency, and hypoxia. Induced autophagy eliminates the...

journal_title：Advances in experimental medicine and biology

authors： Wang Y,Zhang H

更新日期：2019-01-01 00:00:00

abstract：:The allosteric property of globular proteins is applauded as their intrinsic ability to regulate distant sites, and this property further plays a critical role in a wide variety of cellular regulatory mechanisms. Recent advancements and studies have revealed the manifestation of allostery in intrinsically disordered p...

journal_title：Advances in experimental medicine and biology

authors： Rehman AU,Rahman MU,Arshad T,Chen HF

更新日期：2019-01-01 00:00:00

abstract：:The process of creating a translation-competent mRNA is highly complex and involves numerous steps including transcription, splicing, addition of modifications, and, finally, export to the cytoplasm. Historically, much of the research on regulation of gene expression at the level of the mRNA has been focused on either...

journal_title：Advances in experimental medicine and biology

authors： Scott DD,Aguilar LC,Kramar M,Oeffinger M

更新日期：2019-01-01 00:00:00

abstract：:An allosteric mechanism refers to the biological regulation process wherein macromolecules propagate the effect of ligand binding at one site to a spatially distant orthosteric locus, thus affecting activity. The theory has remained a trending topic in biology research for over 50 years, since the understanding of all...

journal_title：Advances in experimental medicine and biology

authors： Song K,Zhang J,Lu S

更新日期：2019-01-01 00:00:00

abstract：:Percutaneous vertebroplasty is a treatment option in vertebral compression fractures (VCF). The aim of the study was to propose the mathematical calculation of the "optimum volume" of acrylic cement filling of the vertebral body, depending on the severity of a fracture. Two hundred computed tomography (CT) scans of ve...

journal_title：Advances in experimental medicine and biology

authors： Dzierżanowski J,Winklewski PJ,Skotarczak M,Baczkowska-Waliszewska Z,Szmuda T,Zdanowski S,Radkowski M,Łuczkiewicz P,Czapiewski P,Słoniewski P,Szurowska E,Demkow U,Szarmach A

更新日期：2019-01-01 00:00:00

abstract：:Digenetic trematodes form a major group of human parasites, affecting a large number of humans, especially in endemic foci. Over 100 species have been reported infecting humans, including blood, lung, liver, and intestinal parasites. Traditionally, trematode infections have been diagnosed by parasitological methods ba...

journal_title：Advances in experimental medicine and biology

authors： Esteban JG,Muñoz-Antoli C,Toledo R,Ash LR

更新日期：2019-01-01 00:00:00

abstract：:Myocardial ischemia-reperfusion (IR) injury during acute myocardial infarction or open-heart surgery would promote oxidative stress, leading to the accumulation of reactive aldehydes that cause cardiac damage. It has been well demonstrated that aldehyde dehydrogenase (ALDH)-2 is an important cardioprotective enzyme fo...

journal_title：Advances in experimental medicine and biology

authors： Ding J,Yang Z,Ma H,Zhang H

更新日期：2019-01-01 00:00:00

abstract：:Fascioliasis is a major parasitic disease caused by the digenetic trematodes Fasciola hepatica and Fasciola gigantica. The disease is a well-known veterinary problem of worldwide distribution. Fascioliasis is the vector-borne parasitic disease presenting the widest latitudinal, longitudinal, and altitudinal distributi...

journal_title：Advances in experimental medicine and biology

authors： Mas-Coma S,Valero MA,Bargues MD

更新日期：2019-01-01 00:00:00

abstract：:Cholesterol-protein interactions play a critical role in lipid metabolism and maintenance of cell integrity. To elucidate the molecular mechanisms underlying these interactions, a growing number of studies have focused on determining the crystal structures of a variety of proteins complexed with cholesterol. These inc...

journal_title：Advances in experimental medicine and biology

authors： Ounjian J,Bukiya AN,Rosenhouse-Dantsker A

更新日期：2019-01-01 00:00:00

abstract：:The rennin-angiotensin-aldosterone system (RAAS) has been well documented in regulating blood pressure, fluid volume, and sodium balance. Overactivity of RAAS promotes both systemic and regional glomerular capillary hypertension, which could induce hemodynamic injury to the glomerulus, leading to kidney damage and ren...

journal_title：Advances in experimental medicine and biology

authors： Zhang YY,Yu Y,Yu C

更新日期：2019-01-01 00:00:00

abstract：:Infantile colic, constipation, functional abdominal pain (FAP), and irritable bowel syndrome (IBS) are the most common functional gastrointestinal disorders (FGID). This chapter will review current evidence on the role of probiotics in the treatment of these FGID. The etiology of FGID is considered multifactorial, but...

journal_title：Advances in experimental medicine and biology

authors： Hojsak I

更新日期：2019-01-01 00:00:00

abstract：:Hypoxia, one of the most common causes of kidney injury, is a key pathological condition in various kidney diseases. Renal fibrosis is the terminal pathway involved in the continuous progression of chronic kidney disease (CKD), characterized by glomerulosclerosis and tubulointerstitial fibrosis (TIF). Recent studies h...

journal_title：Advances in experimental medicine and biology

authors： Li ZL,Liu BC

更新日期：2019-01-01 00:00:00

abstract：:Monocytes/macrophages are highly involved in the process of renal injury, repair and fibrosis in many aspects of experimental and human renal diseases. Monocyte-derived macrophages, characterized by high heterogeneity and plasticity, are recruited, activated, and polarized in the whole process of renal fibrotic diseas...

journal_title：Advances in experimental medicine and biology

authors： Meng XM,Mak TS,Lan HY

更新日期：2019-01-01 00:00:00

abstract：:Due to the exponential growth of aging population worldwide, neurodegenerative diseases became a major public health concern. Among them, Alzheimer's disease (AD) prevails as the most common in the elderly, rendering it a research priority. After several decades considering the brain as an insulin-insensitive organ, r...

journal_title：Advances in experimental medicine and biology

authors： Carvalho C,Cardoso SM,Correia SC,Moreira PI

更新日期：2019-01-01 00:00:00

abstract：:Arterial hypertension remains to be a serious problem with considerable morbidity and mortality worldwide in the present age. Hypertension is a major risk factor for cardiovascular diseases such as stroke, myocardial infarction, renal failure, and heart failure. Hypertensive nephropathy is the second leading cause of ...

journal_title：Advances in experimental medicine and biology

authors： Sun HJ

更新日期：2019-01-01 00:00:00

abstract：:The cytoskeleton consists of filamentous protein polymers that form organized structures, contributing to a multitude of cell life aspects. It includes three types of polymers: the actin microfilaments, the microtubules and the intermediate filaments. Decades of research have implicated the cytoskeleton in processes t...

journal_title：Advances in experimental medicine and biology

authors： Kounakis K,Tavernarakis N

更新日期：2019-01-01 00:00:00

abstract：:Psychiatric disorders are too multifactorial to be defined as a primarily inflammatory disorder, and increased inflammatory response is not specific to mental disorder only. Numerous factors are involved in neuroinflammation, and there also are many confounding variables, making it difficult to obtain consistent outco...

journal_title：Advances in experimental medicine and biology

authors： Jeon SW,Yoon HK,Kim YK

更新日期：2019-01-01 00:00:00

abstract：:Schizophrenia is a severe and debilitating psychiatric disorder believed to have neurodevelopmental origins. Several studies have associated energy metabolism dysfunction with the disorder, mostly related to glycolysis alterations. Glucose is the obligatory energy substrate of the brain and glycolysis is the first ste...

journal_title：Advances in experimental medicine and biology

authors： Zuccoli GS,Guest PC,Martins-de-Souza D

更新日期：2019-01-01 00:00:00

abstract：:Animal research in psychiatry suffers from a poor translational value. It is the same for all other disciplines. Our purpose in this chapter is therefore to highlight all the parameters that can lead to a non-reproducibility of interlaboratory experiments as well as intralaboratory. This is to point out the experiment...

journal_title：Advances in experimental medicine and biology

authors： Bourin M

更新日期：2019-01-01 00:00:00

abstract：:Psychiatric disorders such as addiction (substance use and addictive disorders), depression, eating disorders, schizophrenia, and post-traumatic stress disorder (PTSD) are severe, complex, multifactorial mental disorders that carry a high social impact, enormous public health costs, and various comorbidities as well a...

journal_title：Advances in experimental medicine and biology

authors： Nedic Erjavec G,Svob Strac D,Tudor L,Konjevod M,Sagud M,Pivac N

更新日期：2019-01-01 00:00:00

abstract：:Persons suffering from schizophrenia present cognitive impairments that have a major functional impact on their lives. Particularly, executive functions and episodic memory are consistently found to be impaired. Neuroimaging allows the investigation of affected areas of the brain associated with these impairments and,...

journal_title：Advances in experimental medicine and biology

authors： Penadés R,Franck N,González-Vallespí L,Dekerle M

更新日期：2019-01-01 00:00:00

abstract：:Sleep disorders are common in patients with chronic obstructive pulmonary disease (COPD) and are associated with greater disease severity, more frequent exacerbations, greater use of emergency health care, and higher mortality. They may contribute to worsening of COPD course by reducing patients' adherence to treatmen...

journal_title：Advances in experimental medicine and biology

authors： Chabowski M,Łuczak J,Dudek K,Jankowska-Polańska B

更新日期：2019-01-01 00:00:00

abstract：:Ceramides are bioactive sphingolipids that support the structure of the plasma membrane and mediate numerous cell-signaling events in eukaryotic cells. The finding that ceramides act as second messengers transducing cellular signals has attracted substantial attention in several fields of Biology. Since all cells cont...

journal_title：Advances in experimental medicine and biology

authors： Albeituni S,Stiban J

更新日期：2019-01-01 00:00:00

abstract：:The term cardiovascular diseases (CVD) refers to disorders of heart and blood vessels, and include coronary heart disease, cerebrovascular disease, peripheral vascular disease, and heart failure, among others. Atherosclerosis is a common background of these diseases. It is not infrequent that some acute diseases, such...

journal_title：Advances in experimental medicine and biology

authors： Brianza-Padilla M,Bojalil R

更新日期：2019-01-01 00:00:00

abstract：:Polymyxin B is another clinically available polymyxin that has re-emerged in clinical practice to treat infections caused by multi-drug (MDR) or extensively-drug-resistant (XDR) Gram-negative bacteria (GNB). Its chemical structure is very similar to the structure of polymyxin E (colistin). However, since the latter is...

journal_title：Advances in experimental medicine and biology

authors： Rigatto MH,Falci DR,Zavascki AP

更新日期：2019-01-01 00:00:00

abstract：:The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Understanding the mode of action of antibiotics is an important precursor for optimizing their use and development. This chapter provides...

journal_title：Advances in experimental medicine and biology

authors： Li Z,Velkov T

更新日期：2019-01-01 00:00:00

abstract：:Molecules encoded by the Major Histocompatibility Complex (MHC) bind self or foreign peptides and display these at the cell surface for recognition by receptors on T lymphocytes (designated T cell receptors-TCR) or on natural killer (NK) cells. These ligand/receptor interactions govern T cell and NK cell development a...

journal_title：Advances in experimental medicine and biology

authors： Jiang J,Natarajan K,Margulies DH

更新日期：2019-01-01 00:00:00

abstract：:Respiratory failure is one of the most important risk factors for diagnostic bronchofiberoscopy (BF), whereas therapeutic bronchoscopies are typically performed in intubated patients. Only a few published studies analyzed the outcomes of noninvasive mechanical ventilation (NIV)-facilitated BF. In this case series, we ...

journal_title：Advances in experimental medicine and biology

authors： Skoczyński S,Minarowski Ł,Tobiczyk E,Oraczewska A,Glinka K,Ficek K,Mróz R,Barczyk A

更新日期：2019-01-01 00:00:00

abstract：:Neurodegeneration with brain iron accumulation (NBIA) is a group of seriously devastating and life-threatening rare monogenic diseases characterized by focal iron accumulation in the brain. The main symptoms of NBIA comprise progressive movement disorder, often including painful dystonia, parkinsonism, mental disabili...

journal_title：Advances in experimental medicine and biology

authors： Levi S,Cozzi A,Santambrogio P

更新日期：2019-01-01 00:00:00

abstract：:Based on the insights gleaned from decades of research, it seems clear that mechanistic target of rapamycin (mTOR) is an essential signaling node that integrates environmental clues for regulation of cell survival, metabolism and proliferation of the cells. However, overwhelmingly increasing scientific evidence has ad...

journal_title：Advances in experimental medicine and biology

authors： Butt G,Shahwar D,Qureshi MZ,Attar R,Akram M,Birinci Y,Karatoprak GS,Gasparri ML,Farooqi AA

更新日期：2019-01-01 00:00:00

abstract：:The term "autophagy", which means "self (auto) - eating (phagy)", describes a catabolic process that is evolutionarially conserved among all eukaryotes. Although autophagy is mainly accepted as a cell survival mechanism, it also modulates the process known as "type II cell death". AKT/mTOR pathway is an upstream activ...

journal_title：Advances in experimental medicine and biology

authors： Romero MA,Bayraktar Ekmekcigil O,Bagca BG,Avci CB,Sabitaliyevich UY,Zhenisovna TG,Aras A,Farooqi AA

更新日期：2019-01-01 00:00:00

abstract：:Identification of thyroid stem cells in the past few years has made important contributions to our understanding of the cellular and molecular mechanisms that induce tissue regeneration and repair. Embryonic stem (ES) cells and induced-pluripotent stem cells have been used to establish reliable protocols to obtain mat...

journal_title：Advances in experimental medicine and biology

authors： Zito G,Coppola A,Pizzolanti G,Giordano C

更新日期：2019-01-01 00:00:00

abstract：:This review discusses new developments in Förster resonance energy transfer (FRET) microscopy and its application to cellular receptors. The method is based on the kinetic theory of FRET, which can be used to predict FRET not only in dimers, but also higher order oligomers of donor and acceptor fluorophores. Models ba...

journal_title：Advances in experimental medicine and biology

authors： Corby MJ,Raicu V,Frick DN

更新日期：2019-01-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is classified as an autoimmune disease which progressively results in the depletion of insulin-secreting β-cells. Consequently, the insulin secretion stops leading to hyperglycemic situations within the body. Under severe conditions, it also causes multi-organ diabetes-associated dysfun...

journal_title：Advances in experimental medicine and biology

authors： Farooq T,Rehman K,Hameed A,Akash MSH

更新日期：2019-01-01 00:00:00

abstract：:Gestational diabetes mellitus is a hyperglycaemic state first recognised in pregnancy. GDM affects both mother and child. Women with GDM and their new-borns are at risk of developing type 2 diabetes in the future. The screening and diagnostic criteria for GDM are inconsistent and thus novel biomarkers of GDM are requi...

journal_title：Advances in experimental medicine and biology

authors： Khambule L,George JA

更新日期：2019-01-01 00:00:00